10 US cities that are perfect for a 48-hour weekend getaway

Looking for a quick getaway? The kind of place you can hit on a Friday, leave on a Sunday, and feel like you've had a true vacation?We're happy to say that many of the country's most rewarding cities are compact enough that you can experience all the highlights in a two-day weekend. In these manageable-sized destinations, you can explore cultural sights and historic neighborhoods, eat your way through delicious food scenes, immerse into nature and not feel like you've been running nonstop or have FOMO that you've missed the best parts.Ready for a great escape? Here are 10 perfect U.S. cities for a quick weekend getaway.Related: The most romantic hotels near major US cities for a weekend getawayKey WestCAVAN IMAGES/GETTY IMAGESThe southernmost city in the continental U.S. delivers Caribbean vibes, with no passport required. In fact, the colorful conch houses, turquoise water and the lively scene on Duval Street all make Key West feel worlds away from mainland Florida, even though you can drive here in just a few hours from Miami.Hop on the tram to see the historic district and stop in at the Ernest Hemingway Home & Museum (keep an eye out for the six-toed cats, all descendents f...